From June 24th to 26th, Bacclean participated in the highly anticipated CPHI China 2025, which was grandly held and successfully concluded at the Shanghai New International Expo Center.
The 26th National Hospital Construction Conference (CHCC2025) was held grandly at the Wuhan International Expo Center from May 24 to 26, 2025. During this exhibition, Bacclean, with its professional technical strength, high-quality product services, and innovative solutions, fully demonstrated its core competitiveness in the hospital purification field, attracting many industry colleagues to exchange technologies and solutions in the medical purification field together.
The 16th ASIA PHARMA EXPO came to a successful conclusion at The Asia Pharma Expo In Bangladesh on Feb. 13th,2025. Guangzhou Bacclean was very pleasant to appeared together with its distributors on that day.
Separatorless HEPA filters frequently suffer from three major faults during commissioning and long-term operation: PAO leakage detection failure, fluctuating pressure drop, and hot melt adhesive line failure. Fault root causes fall into three categories: manufacturing defects of the filter itself; issues with supporting FFUs, air supply frame, sealing rings; improper storage, transportation, installation and maintenance operations. Similar fault symptoms may stem from entirely different root causes. If the filter quality is directly judged as defective and repeated disassembly is carried out blindly, it will further damage the equipment and delay project commissioning progress. This article sorts out frequent on-site faults, analyzes inducing factors, and provides step-by-step troubleshooting and handling solutions to help engineering, validation and maintenance personnel quickly locate problems.
Gel-seal HEPA filters are frequently evaluated between leading domestic manufacturers and imported brands for high-grade projects such as Grade A/B biopharmaceutical cleanrooms and biosafety laboratories. For a long period, imported gel-seal HEPA filters occupied the major share of high-end cleanroom projects in China. In recent years, however, continuous technical iteration by top domestic purification equipment manufacturers has enabled qualified domestic products to replace imported options in numerous new construction, renovation and expansion projects.
Most failures of high‑temperature resistant HEPA filters fall into three major categories: hot‑state leakage, rapid abnormal rise of pressure differential, and premature aging of sealing components. Root causes can be grouped into three aspects: manufacturing defects of filter materials; defects of matching components such as equipment flanges and gaskets; improper operations during installation, temperature ramping and disinfection & maintenance. Many failures perform perfectly under ambient temperature and only emerge after temperature rise, which are easily misjudged as inherent filter quality defects. This paper sorts out frequent field faults, analyzes root causes, and provides step‑by‑step troubleshooting workflows, helping equipment, validation and maintenance personnel quickly identify and resolve issues.
The HEPA filter of a horizontal laminar flow clean bench shall not be replaced merely according to service time. Its replacement should be comprehensively determined in combination with airflow velocity, pressure resistance, leak test results and cleanliness variation. Under normal operating conditions, the general replacement cycle of the HEPA filter ranges from 12 to 36 months. The cycle will be greatly shortened in dusty environments, with high operation frequency, continuous long-time running, or inadequate maintenance of the pre-filter.
Separated HEPA filters are core filtration components for cleanroom terminal air supply, laminar flow hoods, air shower tunnels, negative pressure weighing exhaust and other high-load working conditions. There is a large price gap among products on the market. Many low-cost products only match the external dimensions, while obvious gaps exist in filter media, manufacturing process, sealing, pressure drop and dust holding capacity. Problems such as dust leakage, rapid pressure drop rise, short service life and failed PAO leak test tend to occur in the later stage. When selecting premium products, focus on the five core indicators below, and verify them together with working conditions and matching sealing forms.
In GMP pharmaceutical workshops, QC laboratories, raw material dispensing, high-potency powder handling, and pathogenic microorganism testing, both negative pressure weighing booths and biological safety cabinets feature negative pressure protection. Many users confuse the two and mistakenly substitute one for the other, which may lead to cross-contamination of products, personnel exposure, and non-compliance during qualification audits. Although both rely on negative pressure airflow to contain aerosol dispersion, they differ completely in design orientation, protected targets, airflow patterns, protection levels and applicable working conditions. This article analyzes the equipment from core principles, protection objectives, classification, application scenarios, key distinctions and selection guidelines.
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