The core of the daily maintenance of a cleanroom is to continuously control contaminants and ensure the normal operation of equipment to maintain a stable clean environment. It mainly covers four aspects: environmental monitoring, equipment maintenance, cleaning management, and personnel regulations.

Real-time monitoring and recording of environmental parameters
Key environmental indicators should be inspected and recorded regularly to ensure compliance with the cleanroom grade requirements. Any abnormalities should be dealt with promptly.
Cleanliness monitoring: Use particle counters to regularly detect the quantity and size of suspended particles in the air, with a focus on the core areas of production or experiments.
Temperature and humidity control: Real-time monitoring is carried out through temperature and humidity sensors. Generally, a temperature fluctuation of ±2℃ and a humidity fluctuation of ±5% are required to prevent abnormal temperature and humidity from affecting products or experiments.
Differential pressure management: Maintain positive pressure (or negative pressure, such as in a biosafety laboratory) between the clean room and adjacent non-clean areas to prevent external contamination from seeping in. Check the reading of the differential pressure gauge daily and record it.
2. Maintenance and repair of core equipment
The air conditioning, filtration, disinfection and other equipment in a clean room are the foundation for maintaining a clean environment and need to be maintained on a regular basis.
Air filtration system: The primary filter should be replaced every 1 to 3 months, the medium-efficiency filter every 3 to 6 months, and the high-efficiency air filter (HEPA) should be inspected for integrity every 1 to 2 years. If leakage or resistance exceeds the standard, it should be replaced in time.
Air conditioning and ventilation equipment: Check the operating status of components such as the fan, coil, and humidifier of the air conditioning unit every week. Clean the condensate pan monthly to prevent the growth of microorganisms.
Disinfection equipment such as ultraviolet disinfection lamps and ozone generators need to be regularly inspected for their service life and disinfection effect to ensure that the number of environmental microorganisms meets the standards after disinfection.
3. Management of cleaning and disinfection in clean areas
Cleaning work should follow the principle of “from high-cleanliness areas to low-cleanliness areas, from inside to outside, and from top to bottom” to avoid cross-contamination.
Daily cleaning: Use a dedicated lint-free cloth and mop every day, and wipe the floor, walls and equipment surfaces with neutral detergent. Do not use cleaning tools that can produce fibers or dust.
Regular disinfection: According to industry requirements (such as the pharmaceutical industry), comprehensive disinfection should be carried out weekly or monthly. Methods such as wiping, spraying or fumigation can be adopted to ensure the elimination of bacteria, mold and other microorganisms in the environment.
Waste disposal: Waste in the clean area should be placed in dedicated sealed bags and promptly transferred to non-clean areas to prevent accumulation and contamination within the clean area.
4. Implementation of personnel and material standards
Personnel and materials are the main sources of contamination outside the clean room, and the risk of introduction should be reduced through daily management.
Personnel management: Supervise personnel entering the clean room to strictly follow the changing procedures (such as wearing dust-free suits, hand washing and disinfection, and air shower), prohibit the carrying of irrelevant items, and regularly conduct clean awareness training for personnel.
Material control: All materials entering the clean room must undergo cleaning, disinfection or sterilization treatment (such as ultraviolet disinfection through transfer Windows), and the outer packaging must be removed in the buffer zone to avoid the introduction of dust or microorganisms.