Daily inspection of the DOP (PAO) laminar transfer window focuses on the integrity scanning and leak detection of the high-efficiency filters to ensure no leakage and that the filtration efficiency meets the standards. This is a key daily inspection for controlling contamination in the clean area.
\nI. Inspection Objectives
\nVerify that the HEPA\/ULPA filters are undamaged and leak-free
\nConfirm the integrity of the sealing structure (frame, joint, installation surface)
\nMeet the compliance requirements of GMP, ISO 14644, GB 50591, etc. for clean rooms
\nII. Inspection Cycle (Daily \/ Routine)
\nDaily inspection: per shift \/ daily (visual + simple functional check)
\nRegular DOP scanning: once every quarter (key areas can be monthly)
\nAnnual full performance: including DOP, air velocity, cleanliness, pressure difference, interlock
\nIII. Preparations Before Inspection
\n1. Equipment and Consumables
\nAerosol generator (heated DOP \/ cold PAO)
\nAerosol photometer (with upstream\/downstream dual channels, accuracy 0.01%)
\nWind speed meter, pressure gauge, dust particle counter
\nClean cloths, alcohol, sealant (for backup)
\n2. Environment and Status
\nThe transfer window is operating normally (fan, UV, interlock, self-cleaning)
\nThere is no cross-operation in the clean area, adjacent doors\/windows are closed
\nThe instrument is preheated for \u2265 15 minutes, calibrated \/ reset
\nClean the surface of the filter, static pressure box, and outflow surface
\n3. Position Arrangement (Laminar Transfer Window)
\nUpstream: fan inlet \/ static pressure box (dust generation + sampling)
\nDownstream: the entire area of the filter outlet surface, frame, joint, installation sealing surface
\nKey area: corners, sealing strips, and joints with walls\/cabinets
\nIV. DOP Inspection Standard Process (Scanning Method)
\n1. Establishing upstream dust emission and benchmark
\nConnect the generator to the upstream, adjust the concentration to 10\u201330 \u03bcg\/L (stable for \u2265 5 minutes)
\nSet the photometer to **% transmittance**, alarm threshold **\u22640.01%** (commonly used in GMP\/ISO)
\nRecord the upstream concentration C\u2080, ensuring the fluctuation **\u2264\u00b110%**
\n2. Downstream scanning for leak detection (core step)
\nProbe 1\u20132 cm away from the outflow surface, speed **\u22645 cm\/s**
\nPathway reciprocates, overlapping \u2265 50%, covering the entire filter surface + seal
\nFocus on scanning: frame, sealing strip, joint, installation fixation point
\nReal-time reading, **\u22650.01%** determines leakage, mark the location
\n3. Leak Handling and Re-inspection
\nMinor leakage: clean + re-seal \/ re-tighten
\nDamaged \/ irreparable: replace the filter
\nAfter repair, re-inspect the entire area until qualified
\n4. Wind Speed and Self-cleaning Verification (Supporting Daily)
\nLaminar surface wind speed: 0.36\u20130.54 m\/s (vertical single-direction flow)
\nSelf-cleaning time: \u2264 5\u201310 minutes (reaches the target cleanliness)
\nPressure difference: \u2265 5 Pa (clean side higher than non-clean side)
\nV. Qualified Judgment Criteria
\nLeakage rate: throughout the area **\u22640.01%** (no alarm points)
\nWind speed: uniform on the laminar surface, within the standard range
\nSelf-cleaning: quickly reaches the target cleanliness after startup, no continuous contamination
\nInterlock \/ UV \/ Disinfection: functions are normal
\nVI. Daily Record and Management
\nRecord: date, personnel, instrument, upstream concentration, inspection results, leakage points, handling measures, re-inspection conclusion
\nArchive: save **\u22653 years** (satisfies GMP audit traceability)
\nTrend: establish quarterly\/yearly trend charts, warn of aging \/ failure
\nVII. Common Problems and Solutions
\nReading is high but no obvious leakage points: clean the probe\/filter surface, re-calibrate, confirm the upstream concentration is stable
\nContinuous leakage in the frame: check the aging \/ damage of the sealing strip, installation flatness, replace if necessary Local Hotspots: Mostly due to damaged filter paper \/ pinholes. It is recommended to replace the filter directly.
\nVIII. Safety and Compliance Tips
\nDOP\/PAO are oily aerosols. During testing, wear protective masks and goggles, and ensure good ventilation.
\nAfter testing, thoroughly clean the transfer window and the ventilation duct to avoid residual substances that may affect production.
\nPrioritize the use of PAO (which is safer and less toxic) to replace traditional DOP, in line with modern clean standards<\/p>","protected":false},"excerpt":{"rendered":"
Daily inspection of the DOP (PAO) laminar transfer window focuses on the integrity scanning and leak detection of the high-efficiency filters to ensure no leakage and that the filtration efficiency meets the standards. This is a key daily inspection for controlling contamination in the clean area. I. Inspection Objectives Verify that the HEPA\/ULPA filters are […]<\/p>","protected":false},"author":3,"featured_media":4884,"comment_status":"open","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"footnotes":""},"categories":[92],"tags":[],"class_list":["post-5133","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-industry-technology"],"acf":[],"_links":{"self":[{"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/posts\/5133","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/users\/3"}],"replies":[{"embeddable":true,"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/comments?post=5133"}],"version-history":[{"count":1,"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/posts\/5133\/revisions"}],"predecessor-version":[{"id":5134,"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/posts\/5133\/revisions\/5134"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/media\/4884"}],"wp:attachment":[{"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/media?parent=5133"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/categories?post=5133"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/www.bacintl.com\/fr\/wp-json\/wp\/v2\/tags?post=5133"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}